Annotating single amino acid polymorphisms in the UniProt/Swiss-Prot knowledgebase
نویسندگان
چکیده
منابع مشابه
In silico prediction of deleterious single amino acid polymorphisms from amino acid sequence
Molecular cause of human disease retains as one of the most attractive scientific research targets for decades. An effective approach toward this topic is analysis and identification of disease-related amino acid polymorphisms. In this work, we developed a concise and promising deleterious amino acid polymorphism identification method SeqSubPred based on 44 features solely extracted from protei...
متن کاملThe SWISS-PROT protein knowledgebase and its supplement TrEMBL in 2003
The SWISS-PROT protein knowledgebase (http://www.expasy.org/sprot/ and http://www.ebi.ac.uk/swissprot/) connects amino acid sequences with the current knowledge in the Life Sciences. Each protein entry provides an interdisciplinary overview of relevant information by bringing together experimental results, computed features and sometimes even contradictory conclusions. Detailed expertise that g...
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Cellular interleukin 10s (cIL-10s) of human and murine origin have extensive sequence and structural homology to the Epstein-Barr virus BCRF-I gene product, known as viral IL-10 (vIL-10). Although these cytokines share many immunosuppressive properties, vIL-10 lacks several of the immunostimulatory activities of cIL-10 on certain cell types. The molecular and cellular bases for this dichotomy a...
متن کاملProt-Class: A bioinformatics tool for protein classification based on amino acid signatures
Knowledge about characteristics shared across known members of a protein family enables their identification within the complete set of proteins in an organism. Shared features are usually expressed through motifs, which can incorporate specific patterns and even amino acid (AA) biases. Based on a set of classification patterns and biases it can be determined which additional proteins may belon...
متن کاملEasy retrieval of single amino-acid polymorphisms and phenotype information using SwissVar
SUMMARY The SwissVar portal provides access to a comprehensive collection of single amino acid polymorphisms and diseases in the UniProtKB/Swiss-Prot database via a unique search engine. In particular, it gives direct access to the newly improved Swiss-Prot variant pages. The key strength of this portal is that it provides a possibility to query for similar diseases, as well as the underlying p...
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ژورنال
عنوان ژورنال: Human Mutation
سال: 2008
ISSN: 1059-7794,1098-1004
DOI: 10.1002/humu.20671